A chronic high phosphate intake in mice is detrimental for bone health without major renal alterations

Abstract Background Phosphate intake has increased in the last decades due to a higher consumption of processed foods. This is detrimental for patients with chronic kidney disease, increasing mortality and cardiovascular disease risk accelerating dysfunction. Whether high phosphate diet also healthy population still under debate. Methods We fed mature adult mice over period 1 year either (1.2% w/w) or standard (0.6% diet, investigated impact on mineral homeostasis, function bone health. Results The plasma phosphate, parathyroid hormone (PTH) calcitriol levels, no change fibroblast growth factor 23 levels. Urinary calcium ammonium excretion were increased. Measured glomerular filtration rate was apparently unaffected, while blood urea lower clearance animals diet. No observed creatinine Blood urinary pH more acidic paralleled by resorption Total cortical density this effect independent PTH levels observed. Conclusions A did not cause major renal alterations, but affected negatively health, decreasing density.